Usage of metformin for treating alzheimer's disease. Some reports on this blog.
Diabetes and Alzheimer's disease: focus on metformin
There is a relationship between insulin metabolism and cognitive function. "Insulin resistance increases the risk of Alzheimer's disease and is a risk factor of several that should be excluded or treated." This recommends the non-profit Alzheimer's Research Initiative eV (AFI) in their free booklet "Diabetes and Alzheimer's disease: Risks know and avoid."
The interaction between diabetes and Alzheimer's disease, therefore, raises the question of whether diabetes medications may also exert an effect against Alzheimer's. The focus of Alzheimer's research is here especially the drug metformin, suspect by the researchers for some time that it can prevent cell death in Alzheimer's patients. Current research results of Jing Wang of the Hospital for Sick Children, University of Toronto (Canada) seem to confirm this now. Maze experiments in mice treated with metformin showed significantly more capable of learning than their untreated counterparts. Published the results of their research team led by Jing Wang in the journal "Cell Stem Cell".
The scientists now hope that metformin could form the basis for new therapeutic strategies for neurological diseases like Alzheimer's. For this purpose, further research is needed, because in another study of monotherapy with metformin in elderly diabetic patients was already in front of a not inconsiderable risk warned. While metformin in combination with insulin decreases the formation of typical alzheimer amyloid beta peptides significantly. However, caution is advised when insulin is absent. Then there could be a significant increase in the formation of amyloid plaques in use of metformin.
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